Many studies proved that concurrent administration of Ciprofloxacin and Sucralfate reduces the maximum concentration of Ciprofloxacin in plasma to approximately 1/10 level.
Combined use of ciprofloxacin and sucralfate. https://www.ncbi.nlm.nih.gov/pubmed/1877263
Failure of Prostatitis Treatment Secondary to Probable Ciprofloxacin‐Sucralfate Drug Interaction https://www.researchgate.net/publication/14383813_Failure_of_Prostatitis_Treatment_Secondary_to_Probable_Ciprofloxacin-Sucralfate_Drug_Interaction
Like Rifaximin, the unabsorbed Ciprofloxacin is more effective to act directly inside the colon?
Or because of the chelate of Ciprofloxacin-Aluminum (of Sucralfate), the chelated Ciprofloxacin is no more effective?
I've tried to find long time but no luck.
If somebody helps me with scientific evidences, it would be highly appreciated!