As explained in the answer of another question, a difficulty of cancer therapeutics is the delivery of the therapeutic to only the cancerous cells, which need to be identified among healthy cells.
The T-cell receptor (TCR) can identify cancerous cells.
It has been noted by Schaffer et al. that viral capsids can be engineered to incorporate parts of proteins for cellular targeting.
The range of lengths of viral capsids is 20 - 200 nanometers long. T-cell receptor length is around 7 nanometers long. I couldn't find the range of lengths of the normal proteins used for cellular targeting by engineering them to viral capsids.
If the size of a T-cell receptor might be about the same as the usual protein used for cellular targeting, has a T-cell receptor been engineered on a viral capsid for targeting cancerous cells with therapeutics?
A Google search for the use of T-cell receptors as receptors on viral capsids returned no relevant answers. Thank you for your consideration in advance!
